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The mixed DNA from all races might have given the virus during its replication a key for better transmission to any race. And I understand some clots as well, including with the Pfizer vaccine.I am asking this also because I want to get vaccinated but just like the previous comment with the autoimmune condition, I have had an autoimmune condition, the hives on and off for the past 15years (I am not that young anymore though), cause unknown although stress and some chemicals make them worse. There is no damage when the spike protein is just inside a cell. Can not happen as this paper suggests. Yuan, Atul Malhotra, Uri Manor, Shengpeng Wang, Zu-Yi Yuan and John Y-J. Updated 13 Apr 2021. The spike protein is unique to SARS-CoV-2 - it doesn't look like other proteins your body makes. My statement that the spike protein migrates to the surface of the cell so as to be recognized by the immune system is not a very accurate simplification. Of course, none of this even begins to account for how vaccines will alter our immune response, for better or for worse, to COVID-19 variants. Previous studies have shown a similar effect when cells were exposed to the SARS-CoV-2 virus, but this is the first study to show that the damage occurs when cells are exposed to the spike protein on its own. In fact, the antibodies that the mother has can go through the breast milk to the baby and may only serve maybe to protect the baby a little bit. That could explain why some people have strokes, and why some people have issues in other parts of the body. Because it is stopped once made, because the cell recognizes is as foreign protein and send it off for destruction, and hands its smashed parts from the endoplasmic reticulum (ER) to the MCH mechanism which hands it off to the T-Cell immune system for removal. extended to treat other RNA viruses in the future. Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients. SARS-CoV-2 Spike Protein Impairs Endothelial Function via It is incredibly safe., A second study Bridle uses to support his claims is one by Pfizer. Keanna Ghazvini, a Pfizer spokesperson, told us in an email that the document referred to by Bridle, which is mostly in Japanese, is a pharmacokinetics overview of the companys vaccine. Spokesperson, U.S. Food and Drug Administration. Our Immune Systems Blanket the SARS-CoV-2 Spike Protein with Antibodies Heres a step-by-step guide to how they work. We show here that S protein alone can damage vascular endothelial cells (ECs) in vitro and in vivo, manifested by impaired mitochondrial function, decreased ACE2 expression and eNOS activity, and increased glycolysis. Wrapp, Daniel, et al. To fuse its viral membrane with the host cell membrane it substantially changes its shape from an unstable pre-fusion state to a stable post-fusion state. Spokesperson, Pfizer. It is locked in the pre-fusion state to stabilize it not to prevent binding. Prompting an Immune Response The mRNA vaccines builds the protein within the safe environment of the host cell structure from the inside outspikes are not created outside this environment. If provided, your email will not be published or shared. The Salk Institute embodies Jonas Salk's mission to dare to make dreams into reality.